1.调节B细胞在健康和疾病中的存活的分子机制在B细胞中，就像在其他组织中一样，生存/凋亡平衡对稳态至关重要。大量的静息细胞必须维持，以保持多样化的B细胞库。B细胞在外周的长期存活依赖于细胞表面受体转导的生存信号。相反，对细胞凋亡的抵抗，导致生存率的提高，与B细胞恶性肿瘤的发生和发展有关。我们的研究重点是调节B细胞存活的分子。这些分子也与肿瘤进展和转移有关。我们目前正在分析来自不同阶段患者的CLL细胞诱导的生存途径。这些发现可能为新的治疗策略铺平道路，旨在阻断这种生存途径。 2. Regulation of peripheral lymphocytes?? targeting to the LN and sites of inflammation in health and disease. The majority of lymphocytes are capable of tissue selective trafficking (homing), recognizing organ-specific adhesion molecules on specialized endothelial cells. Previous studies focused on the specific recruitment of leukocytes to the lymph nodes (LN) or to sites of inflammation. However, little is known about the molecular mechanisms that negatively control or prevent homing of cells to these sites. Our studies focus on the pathways that restrict homing of specific subsets of immune cells, and thereby fine tune the immune response at specific lymphoid and peripheral tissues. Impaired homing of lymphocytes to peripheral lymph nodes results in attenuated progression of inflammation in various inflammatory models, including asthma, arthritis, inflammatory bowl disease (IBD) and experimental autoimmune encephalomyelitis (EAE). We are currently analyzing the additional pathways that are involved in this homing regulation.